Endocrine Abstracts

Alzheimer’s disease (AD) is a neurodegenerative diseasethat is manifested by a progressive loss of cognitive and behavioral function. In previous studies, we have constructed a predictive model for the classification of AD patients based on levels of circulating steroids and their polar conjugates.Both AD and Type 2 diabetes mellitus(T2DM) are well known to affect the levels of some steroid hormones, however, in the opposite direction, and in a gen...

A 36-year-old male presented to the emergency department with a 24-hour history of mutism, paranoia and 3-day history of social withdrawal. He was unable to engage with healthcare professionals and the history was elicited from his mother. Due to a background of mild depression, an acute psychotic diagnosis was initially pursued. A CT scan on admission revealed a large pituitary lesion. A pituitary MRI scan thereafter demonstrated a large 25 × 30 × 18 mm sellar and s...

This work aimed to evaluate pituitary–adrenal axis and tissue metabolism of cortisol in patients with long standing type one diabetes.Fifty patients with diabetes type 1 were investigated; age 38±10 years (mean±S.D.), age at diagnosis 25.5±10 years, disease duration 15±8 years, BMI 24.5±2.7 kg/cm2, HbA1c 7.2±1.2%. Control group consisted of 40 healthy volunteers.The study...

Introduction: Obesity epidemic has a considerable effect on the health of the population. Obesity is connected with infertility and hypogonadism. It is known that obese men have a low testosterone and higher estradiol level. The assumed mechanism would be increased testosterone aromatization in adipose tissue and a lower SHBG level, which means a decrease of overall testosterone. The aim of this study was to describe the changes of steroidogenesis with obese men.<p class="...

Background: Subclinical hypothyroidism is common in pregnancy affecting about 5% of all pregnant women, and is associated with adverse pregnancy outcomes. There is a general consensus that subclinical hypothyroidism detected during pregnancy should be treated with L-thyroxine (Stagnaro-green et al. 2011, DeGroot et al. 2012). However, it is unclear whether the treatment should be limited only during the pregnancy or continued long-term. Therefo...

Levothyroxine suppression therapy, i.e. keeping the TSH value below 0.3 mIU/l with the aim to reduce the total thyroidal tissue or nodule volume, is an arguable and controversial issue not only due to the effect upon nodule volume but also because of the extent of necessary suppression, the effect of incomplete suppression, long-time therapeutic effects and risk of cardiovascular problems and osteoporosis.The incidence of nodular alterations rises with a...

Introduction: Waist circumference serves as a key indicator of abdominal obesity and predictor of cardiovascular and metabolic risk even in children. Under the current WHO standard methodology, waist circumference is measured midway between the lowest rib and the iliac crest. However, comparison of current and earlier data is complicated as different waist circumference measurement methodologies have been used in the past. For instance, previous Czech studies commonly worked w...

Recently we have completed steroid metabolomic study including unconjugated (n=39) and conjugated steroids (n=30) in maternal and fetal body fluids using GC-MS method with two separate multicomponent analyses (for unconjugated steroids and steroid polar conjugates). Our previous data indicate that primarily oxidative isoforms of pluripotent 17β-hydroxysteroid dehydrogenases and aldoketoreductases in placental tissue close to the fetal compartment convert 3&#...

Recently we demonstrated a close correlation between the gestational age (GA) and steroid metabolome in maternal and fetal body fluids using multivariate models including both unconjugated (n=39) and conjugated steroids (n=30) that were measured by GC-MS method including two separate multicomponent analyses (for unconjugated steroids and steroid polar conjugates). We focused on the comparison of the predictive value of the levels of unconjugated steroids alone, c...

Introduction: Glucose homeostasis is central to the understanding of diabetes and is influenced by hormones and by substrate flux. This implies a non-linear system which has been confirmed by time series analysis. A dynamic systems approach is required for describing the inter-relationship of glucose and insulin and we describe a method that measures a mathematical domain of glucose homeostasis termed the observed variability and lability (OVAL).Methods:...